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Research Reference Database

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Dosing protocols, half-life tables, and COA-verified vendor pricing in one place. Built for serious researchers — not surface-level content.

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Research Data, Protocols & Pricing

Click any peptide to expand full research data including dosage ranges, administration routes, cycle protocols, half-life, and verified vendor pricing. For educational purposes only — not medical advice.

Bacteriostatic Water
BAC Water · Required for Peptide Reconstitution
★ ESSENTIALS
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🧪 Use: Reconstitution solventPreservative: 0.9% benzyl alcohol🔒 Shelf life: 28 days opened

Bacteriostatic water is the only correct solvent for peptide reconstitution. The benzyl alcohol keeps your reconstituted peptide stable for up to 28–30 days refrigerated.

Why It Has to Be BAC Water

Bacteriostatic water contains 0.9% benzyl alcohol, which prevents bacterial growth in your vial after the seal is broken. Regular sterile water has no preservative — once opened, it's a contamination risk within hours. BAC water keeps your reconstituted peptide stable for 28–30 days when refrigerated at 2–8°C.

Never use tap water, saline (for IVs), or plain sterile water for peptide reconstitution.

Sizes

10mL vials — standard size, handles most single-peptide protocols. 30mL vials — better value if running multiple peptides simultaneously or doing frequent reconstitutions.

Reconstitution Kit
Everything you need to prep and inject any peptide
★ ESSENTIALS

6-Step Reconstitution Protocol

1
Gather supplies — peptide vial, bacteriostatic water, insulin syringe, alcohol swabs, sharps container.
2
Wipe both vial tops with an alcohol swab. Let dry for 10 seconds.
3
Draw BAC water into syringe. Standard: 1–2mL per vial depending on desired concentration.
4
Inject slowly down the inside wall of the peptide vial — never spray directly onto the powder.
5
Swirl gently until fully dissolved. Do not shake. Solution should be clear and colorless.
6
Refrigerate immediately at 2–8°C. Label with date. Use within 28–30 days.

Subcutaneous Injection Guide

1
Choose your site — abdomen (1” from navel) or outer thigh. Rotate sites each injection.
2
Wipe the site with an alcohol swab and let dry completely.
3
Pinch the skin lightly and insert needle at 45–90° angle.
4
Inject slowly — push plunger steadily over 3–5 seconds.
5
Withdraw needle and apply light pressure with a clean swab. Do not rub.
6
Dispose of the used syringe immediately in your sharps container.
For educational reference only. Consult a licensed physician before beginning any injection protocol.
Fat Loss & Metabolic
5 peptides
Retatrutide
GLP-1/GIP/Glucagon Triple Agonist · GLP-3RT
🔥 HOTTEST
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📈 Half-life: ~6 days💉 Route: SubQ injection⏱️ Cycle: 24–36 weeks

Retatrutide is the most powerful weight loss compound in clinical research. Phase 2 trials showed 24% average body weight reduction over 48 weeks. Phase 3 trials ongoing by Eli Lilly.

Complete Research Guide
Retatrutide: Dosage, Protocol & Trials →
Titration charts · Side effects · Full vendor pricing

Mechanism

Retatrutide (LY3437943) is a triagonist activating GLP-1, GIP, and glucagon receptors. GLP-1 reduces appetite and slows gastric emptying. GIP enhances insulin secretion. Glucagon receptor activation increases energy expenditure and drives lipolysis — particularly of visceral fat.

Clinical Evidence

Phase 2 trial (NEJM 2023): up to 24.2% mean body weight reduction at highest dose. Phase 3 trials ongoing under the TRIUMPH program.

Research Dosing Protocol

PhaseDoseFrequency
Weeks 1–40.5–1mgOnce weekly
Weeks 5–81–2mgOnce weekly
Weeks 9–122–4mgOnce weekly
Weeks 13+4–8mgOnce weekly
⚠️ Research use only. GI side effects (nausea, vomiting) are dose-dependent. Titrate slowly.
Tesamorelin
GHRH Analog · Growth Hormone Releasing
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💧 Use: Reconstitution solventPreservative: 0.9% benzyl alcohol🔒 Shelf life: 28 days opened

Bacteriostatic water is the only correct solvent for peptide reconstitution. The 0.9% benzyl alcohol inhibits microbial growth, keeping your reconstituted peptide stable for up to 28–30 days refrigerated. Do not substitute sterile water — it has no preservative and degrades your peptide fast.

Mechanism

Tesamorelin binds GHRH receptors in the pituitary, stimulating pulsatile GH secretion. Unlike exogenous GH, it preserves the natural feedback loop, reducing risk of shutdown.

Key Research Uses

  • Visceral fat reduction
  • Body composition improvement
  • Cognitive function support in older adults

Research Protocol

ParameterValue
Dose1–2mg daily
TimingFasted, before bed
Cycle12–20 weeks
AOD-9604
HGH Fragment 176-191 · Lipolytic
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📈 Half-life: ~30 minutes💉 Route: SubQ injection⏱️ Cycle: 12–16 weeks

AOD-9604 is a fragment of human growth hormone studied specifically for fat metabolism — it targets lipolysis without the blood sugar or IGF-1 effects of full HGH. Reached Phase 2 human trials for obesity research.

Mechanism

AOD-9604 stimulates lipolysis and inhibits lipogenesis by mimicking the way natural HGH regulates fat metabolism. It has no effect on IGF-1 levels or blood glucose.

Research Protocol

ParameterValue
Dose300–500mcg daily
TimingFasted AM
Cycle12–16 weeks
MOTS-c
Mitochondrial-Derived Peptide · Metabolic Regulator
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📈 Half-life: ~4–6 hours💉 Route: SubQ injection⏱️ Cycle: 8–12 weeks

MOTS-c is a peptide produced by your own mitochondria that research shows improves insulin sensitivity, boosts metabolic rate, and has extended lifespan in animal models.

Mechanism

MOTS-c targets the AMPK pathway and regulates glucose metabolism in skeletal muscle. It improves insulin sensitivity and has been demonstrated to reverse age-related metabolic dysfunction in preclinical models.

Research Protocol

ParameterValue
Dose5–10mg
Frequency2–3x weekly
Cycle8–12 weeks
CJC-1295 / Ipamorelin
GHRH + GHRP Blend · GH Secretagogue Stack
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📈 Half-life: CJC ~7d / Ipa ~2h💉 Route: SubQ injection⏱️ Cycle: 12–20 weeks

CJC-1295 and Ipamorelin work together to produce stronger, cleaner growth hormone pulses than either compound alone — without spiking cortisol or prolactin.

Synergy

CJC-1295 stimulates GHRH receptors for sustained baseline GH elevation. Ipamorelin selectively stimulates ghrelin receptors for clean GH pulses. Combined effect is significantly greater than either alone.

Research Protocol

ParameterValue
CJC Dose100–300mcg
Ipa Dose100–300mcg
TimingPre-sleep, fasted
FrequencyDaily to 3x/week
Sermorelin
GHRH 1-29 Analog · Growth Hormone Secretagogue
📈 Half-life: ~10–20 minutes💉 Route: SubQ injection⏱️ Cycle: 3–6 months
Sermorelin stimulates your pituitary to produce growth hormone naturally — preserving the body's own feedback system rather than introducing external GH. FDA-approved diagnostic use with a well-established safety profile.
GH BoostAnti-AgingSleepBody CompositionRecovery
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📈 Half-life: ~10–20 minutes💉 Route: SubQ injection⏱️ Cycle: 3–6 months

Sermorelin stimulates your pituitary to produce growth hormone naturally — preserving the body's own feedback system rather than introducing external GH. FDA-approved diagnostic use with a well-established safety profile.

Mechanism

Sermorelin binds GHRH receptors in the anterior pituitary, stimulating GH synthesis and secretion. It preserves the natural GH feedback loop, reducing the risk of pituitary shutdown seen with exogenous GH use.

Research Protocol

ParameterValue
Dose200–500mcg
TimingBefore bed, fasted
FrequencyDaily or 5 days on/2 off
Recovery & Repair
5 peptides
BPC-157
Body Protection Compound · Gastric Pentadecapeptide
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📈 Half-life: ~4 hours💉 Route: SubQ or IM⏱️ Cycle: 4–12 weeks

BPC-157 has shown remarkable healing effects on muscles, tendons, ligaments, and gut tissue across study after study — making it one of the most researched recovery compounds in the space. Over 100 preclinical studies with consistent results.

Mechanism

BPC-157 promotes angiogenesis, upregulates growth factors, and modulates nitric oxide pathways. It has demonstrated ability to heal tendons, ligaments, bones, and gut tissue in animal models.

Research Protocol

GoalDoseFrequency
Systemic healing250–500mcg1–2x daily
Local injury200–300mcgDaily near site
Gut healing250mcgDaily oral
TB-500
Thymosin Beta-4 Fragment · Systemic Repair
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📈 Half-life: ~3–4 days💉 Route: SubQ or IM⏱️ Cycle: 4–6 weeks

TB-500 is a fragment of a protein your body produces naturally for healing — research shows it supports new blood vessel formation, reduces inflammation, and accelerates repair of slow-healing injuries.

Mechanism

TB-500 promotes actin polymerization and upregulation of Tβ4, which regulates cell migration, proliferation, and survival. It reduces inflammation and promotes healing through multiple pathways including VEGF upregulation.

Research Protocol

PhaseDoseFrequency
Loading (wks 1–4)2–2.5mg2x weekly
Maintenance2mgWeekly
Injury Stack
BPC-157 + TB-500 · Systemic Repair Stack
STACK
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📈 Combo: BPC-157 + TB-500Route: SubQ⏱️ Cycle: 6–12 weeks

BPC-157 and TB-500 together address injury recovery from two angles — local tissue repair and systemic anti-inflammatory support — making this one of the most studied healing combinations available.

Why Stack These

BPC-157 initiates local repair via angiogenesis and growth factor upregulation. TB-500 promotes cell migration and systemic anti-inflammatory effects via actin regulation. Together they address both local and systemic aspects of injury recovery.

Research Protocol

CompoundDoseFrequency
BPC-157250–500mcgDaily
TB-5002–2.5mg2x/week loading, then weekly
GHK-Cu
Copper Peptide · Skin & Regeneration
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📈 Half-life: ~30 minutesRoute: SubQ or topical⏱️ Cycle: Ongoing

GHK-Cu is a copper peptide naturally found in human blood that declines with age — research shows it supports wound healing, collagen production, skin repair, and hair follicle activity.

Mechanism

GHK-Cu activates wound healing, attracts immune cells, and promotes collagen production. It remodels skin and stimulates hair follicle growth while suppressing inflammation.

Research Protocol

RouteDoseFrequency
SubQ injection1–2mgDaily
TopicalApplied to skin1–2x daily
IGF-1 LR3
Insulin-Like Growth Factor 1 Long R3
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📈 Half-life: ~20–30 hours💉 Route: SubQ or IM⏱️ Cycle: 4–6 weeks

IGF-1 LR3 is a modified version of the body's main muscle-building signal, engineered to stay active longer — research shows it promotes muscle cell growth and accelerates recovery.

Mechanism

IGF-1 LR3 binds IGF-1 receptors to stimulate protein synthesis, muscle cell proliferation, and satellite cell activation. The LR3 modification gives it a ~20x longer half-life than native IGF-1.

Research Protocol

ParameterValue
Dose20–60mcg
TimingPost-workout or AM
Cycle4–6 weeks max
⚠️ Hypoglycemia risk. Never use near bedtime. Monitor blood glucose.
Hormone & Longevity
4 peptides
Epithalon
Tetrapeptide · Telomere Activator · Anti-Aging
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📈 Half-life: ~30 minutes💉 Route: SubQ injection⏱️ Cycle: 10–20 days, 2x/year

Epithalon activates telomerase — the enzyme that repairs and lengthens telomeres — and has been studied for longevity effects for over 35 years. Human studies published primarily by Russian researchers.

Mechanism

Epithalon stimulates the pineal gland to produce more melatonin, activates telomerase to elongate telomeres, and normalizes the hypothalamic-pituitary axis.

Research Protocol

ParameterValue
Dose5–10mg daily
Cycle10–20 days
Frequency2x per year
PT-141
Bremelanotide · Melanocortin Receptor Agonist
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📈 Half-life: ~2–3 hours💉 Route: SubQ injection⏱️ Cycle: As needed

PT-141 works directly on the brain's arousal pathways via the central nervous system rather than blood flow, making it effective for both men and women. FDA-approved as Vyleesi for low sexual desire in premenopausal women.

Mechanism

PT-141 activates melanocortin receptors (MC3R and MC4R) in the brain, triggering pathways that increase sexual desire. Unlike PDE5 inhibitors, it acts centrally rather than on the vascular system.

Research Protocol

ParameterValue
Dose1–2mg
Timing45–90 min before activity
FrequencyAs needed, max 1x/72hrs
⚠️ Can cause nausea and transient blood pressure elevation. Start with 1mg.
Selank
NA-Selank Amidate · Anxiolytic Nootropic
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📈 Half-life: ~2–3 minutes (intranasal)💉 Route: Intranasal or SubQ⏱️ Cycle: 10–14 days on/off

Selank is a Russian-developed peptide studied for its ability to reduce anxiety and sharpen cognitive function without the sedation or dependence associated with traditional anxiolytics.

Mechanism

Selank modulates GABA-A receptors and increases BDNF expression. It also regulates IL-6 and enkephalin levels, contributing to its anxiolytic and cognitive effects without causing sedation or dependence.

Research Protocol

ParameterValue
Dose250–3000mcg
RouteIntranasal preferred
Cycle10–14 days on, 10–14 off
Semax
ACTH 4-7 Pro8Gly9Pro10 · Nootropic
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📈 Half-life: ~2 minutes (intranasal)💉 Route: Intranasal⏱️ Cycle: 10–14 days on/off

Semax is one of the most studied nootropic peptides in the world — research shows it raises BDNF levels, supports focus and memory, and has been used clinically in Russia for stroke recovery since the 1980s.

Mechanism

Semax increases BDNF and NGF expression, enhances dopaminergic and serotonergic neurotransmission, and has neuroprotective effects.

Research Protocol

ParameterValue
Dose200–900mcg
RouteIntranasal
Cycle10–14 days on, 10–14 off
Curated Stacks
4 peptides
Recomp Stack
Retatrutide + Tesamorelin · Dual-Pathway Fat Loss
STACK
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🎯 Goal: Body recomposition⏱️ Duration: 16–24 weeks

This combination pairs the most powerful fat loss compound in Phase 3 trials with an FDA-referenced GH stimulator — targeting body fat from two distinct mechanisms simultaneously for aggressive recomposition.

Why This Stack

Retatrutide targets GLP-1, GIP, and glucagon receptors for maximal appetite suppression and lipolysis. Tesamorelin stimulates pulsatile GH release which specifically targets visceral adipose tissue. The two compounds operate on distinct pathways, making the combination synergistic.

Protocol Overview

CompoundDoseFrequency
Retatrutide2–8mg (titrate up)Weekly
Tesamorelin1–2mgDaily
Longevity Stack
Epithalon + GHK-Cu + TA-1 · Anti-Aging Trio
STACK
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🎯 Goal: Anti-aging & longevity⏱️ Duration: 10–20 day cycles

Three of the most evidence-backed longevity peptides combined — Epithalon for telomere support, GHK-Cu for tissue regeneration, and Thymosin Alpha-1 for immune regulation.

Why This Stack

Epithalon addresses telomere shortening. GHK-Cu targets tissue degradation and chronic inflammation. TA-1 addresses immune senescence. Together they provide multi-pathway anti-aging support.

Protocol Overview

CompoundDoseFrequency
Epithalon5–10mgDaily for 10–20 days
GHK-Cu1–2mgDaily
TA-11.6mg2x weekly
KLOW Blend
GHK-Cu + BPC-157 + TB-500 + KPV · Exclusive Blend
BLEND
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💊 Blend: 4-peptide proprietary formula💉 Route: SubQ injection⏱️ Cycle: 6–12 weeks

S1 Research's all-in-one recovery blend combines four synergistic peptides — GHK-Cu, BPC-157, TB-500, and KPV — each targeting a different aspect of healing and inflammation.

Blend Components

  • GHK-Cu — Copper peptide for skin repair and collagen production
  • BPC-157 — Local tissue healing and angiogenesis
  • TB-500 — Systemic anti-inflammatory and cell migration
  • KPV — Anti-inflammatory tripeptide derived from MSH

Protocol

ParameterValue
DosePer vendor instructions
FrequencyDaily or every other day
Cycle6–12 weeks
Glow Blend
BPC-157 + TB-500 + GHK-Cu · Triple Recovery Blend
BLEND
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💊 Blend: BPC-157 + TB-500 + GHK-Cu💉 Route: SubQ injection⏱️ Cycle: 6–12 weeks

A triple healing peptide formulation covering the full recovery spectrum — BPC-157 for tissue repair, TB-500 for systemic inflammation support, and GHK-Cu for collagen and skin regeneration.

Component Synergy

  • BPC-157 — Initiates local tissue repair via VEGF upregulation
  • TB-500 — Systemic anti-inflammatory support and cell migration
  • GHK-Cu — Collagen and elastin production, skin repair

Research Protocol

ParameterValue
FrequencyDaily or every other day
Cycle6–12 weeks
Gut, Systemic & Immune
4 peptides
KPV
Anti-Inflammatory Tripeptide · IBD Research
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📈 Half-life: ~2 hours💊 Route: Oral or SubQ⏱️ Cycle: As needed

KPV is a powerful anti-inflammatory tripeptide — preclinical research has shown it can directly enter gut cells and suppress inflammation, making it one of the most studied compounds for IBD and leaky gut research. Currently studied in animal models and in vitro; human clinical trial data is emerging.

Mechanism

KPV inhibits pro-inflammatory NF-κB pathways and reduces cytokine production (IL-8, TNF-α). It can be taken orally for gut-specific effects as it directly targets intestinal epithelial cells and macrophages.

Research Protocol

ParameterValue
Dose250–500mcg
RouteOral (gut) or SubQ (systemic)
Frequency1–2x daily
LL-37
Cathelicidin Antimicrobial Peptide · Immune Defense
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📈 Half-life: ~2–4 hours💉 Route: SubQ injection⏱️ Cycle: As needed

LL-37 is the only antimicrobial peptide your body produces naturally — research shows it fights bacteria, viruses, and fungi while also supporting wound healing and immune modulation.

Mechanism

LL-37 disrupts bacterial membranes and neutralizes LPS. It also activates formyl peptide receptors and toll-like receptors to modulate both innate and adaptive immune responses.

Research Protocol

ParameterValue
Dose100–300mcg
FrequencyDaily or every other day
Larazotide
Tight Junction Regulator · Leaky Gut
EMERGING
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💊 Route: Oral⏱️ Cycle: As needed

Larazotide is studied specifically for intestinal permeability — research shows it can tighten the junctions between gut cells, making it one of the most clinically investigated compounds for leaky gut and celiac disease.

Mechanism

Larazotide prevents zonulin-induced tight junction disassembly. Zonulin is the primary regulator of intestinal permeability — Larazotide blocks its effect, helping maintain gut barrier integrity.

Research Protocol

ParameterValue
Dose0.5–2mg
RouteOral
TimingBefore meals
VIP
Vasoactive Intestinal Peptide · Immune & Gut
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📈 Half-life: ~1–2 minutes💉 Route: SubQ or intranasal⏱️ Cycle: Varies

VIP is a natural neuropeptide with broad anti-inflammatory effects — research shows it plays important roles in gut health, immune balance, and circadian rhythm regulation.

Mechanism

VIP activates VPAC1 and VPAC2 receptors on immune cells, suppressing Th1/Th17 responses and promoting regulatory T cells. It also reduces TNF-α, IL-6, and other pro-inflammatory cytokines.

Research Protocol

ParameterValue
Dose50–100mcg
Frequency1–2x daily
Skin, Hair & Aesthetics
4 peptides
Snap-8
Acetyl Glutamyl Heptapeptide-3 · Anti-Wrinkle
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📈 Half-life: Topical🧴 Route: Topical application⏱️ Cycle: Ongoing

Snap-8 is studied as a topical alternative to Botox — it works by interfering with the same neuromuscular signaling that causes expression lines, without needles. In vitro and cosmetic clinical studies published; results vary by formulation and concentration.

Mechanism

Snap-8 inhibits SNARE complex formation by mimicking the N-terminal end of SNAP-25. This reduces the release of catecholamines at the neuromuscular junction, relaxing facial muscles that cause wrinkles.

Application Protocol

ParameterValue
Concentration4–10% in cream/serum
ApplicationExpression-prone areas
Frequency2x daily
Matrixyl 3000
Palmitoyl Tripeptide-1 + Tetrapeptide-7 · Collagen
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📈 Half-life: Topical🧴 Route: Topical⏱️ Cycle: Ongoing

Matrixyl 3000 is one of the most studied anti-aging skincare ingredients — cosmetic clinical research has documented meaningful reductions in wrinkle depth when used consistently. Cosmetic clinical trial data published; not a pharmaceutical drug, regulated as a cosmetic ingredient.

Mechanism

The two matrikine peptides in Matrixyl 3000 signal the dermal matrix to repair itself. Palmitoyl tripeptide-1 stimulates collagen synthesis while palmitoyl tetrapeptide-7 reduces pro-inflammatory cytokines (IL-6) in skin tissue.

Application Protocol

ParameterValue
Concentration8% in carrier
FrequencyTwice daily
Results timeline4–8 weeks
Melanotan II
Melanocortin Receptor Agonist · Tanning Peptide
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📈 Half-life: ~30 minutes💉 Route: SubQ injection⏱️ Cycle: As needed

Melanotan II was originally developed as a tanning compound and research shows it stimulates melanin production and has effects on appetite and arousal pathways via the brain's melanocortin receptors. Reached early Phase 2 human trials; not FDA approved. Use with caution — strong systemic effects documented.

Mechanism

MT-II activates melanocortin receptors (MC1R, MC3R, MC4R). MC1R activation in melanocytes increases melanin production. MC4R activation suppresses appetite and has been studied for effects on central arousal mechanisms.

Research Protocol

PhaseDose
Loading0.25–0.5mg daily
Maintenance0.5–1mg as needed
⚠️ Can cause nausea and flushing. Start low. Monitor moles for changes.
AHK-Cu
Copper Peptide · Hair Follicle Activator
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📈 Half-life: Topical🧴 Route: Topical (scalp)⏱️ Cycle: Ongoing

AHK-Cu is a copper peptide studied specifically for hair follicle biology — research shows it activates keratinocyte growth factor and has been documented to increase follicle size in preclinical models. Preclinical animal and in vitro data published; limited human clinical trial data.

Mechanism

AHK-Cu activates KGF (keratinocyte growth factor) which promotes hair follicle proliferation. The copper complex also has antioxidant properties and promotes collagen synthesis in the scalp dermis.

Application Protocol

ParameterValue
Concentration0.1–1% in carrier
ApplicationScalp or skin
Frequency1–2x daily
Advanced & Emerging
7 peptides
Pinealon
Pineal Gland Peptide · Cognitive & Sleep
EMERGING
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📈 Half-life: ~2–3 hours💉 Route: SubQ injection⏱️ Cycle: 10-day cycles

Pinealon is a Russian-developed tripeptide studied for neuroprotection and circadian rhythm support — research shows it has protective effects on brain cells and may support sleep regulation via the pineal gland. Preclinical animal data published primarily in Russian research; limited Western clinical data.

Mechanism

Pinealon is a geroprotective peptide that activates antioxidant defense systems in neurons and regulates melatonin synthesis via the pineal gland. It has shown neuroprotective effects in hypoxia and ischemia models.

Research Protocol

ParameterValue
Dose5–10mg daily
Cycle10 days
Frequency2–4x per year
NAD+
Nicotinamide Adenine Dinucleotide · Cellular Energy
⭐ POPULAR
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💊 Route: SubQ injection or IV⏱️ Cycle: Ongoing / periodic loading

NAD+ is a molecule found in every cell that powers energy production and DNA repair — research shows levels drop ~50% between ages 40 and 60. Injectable forms have been studied for faster restoration than oral supplements.

Mechanism

NAD+ is a critical coenzyme in oxidative phosphorylation, DNA repair via PARP enzymes, and sirtuin activation (SIRT1–7). Declining NAD+ with age is linked to metabolic dysfunction, neurodegeneration, and reduced cellular repair capacity.

Research Protocol

ProtocolDoseFrequency
Loading phase500mgDaily for 5–10 days
Maintenance250–500mgWeekly or bi-weekly
⚠️ Rapid IV administration can cause flushing, nausea, and chest tightness. Always administer SubQ or slow IV push.
Follistatin 344
Myostatin Inhibitor · Muscle Growth
ADVANCED
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📈 Half-life: ~24 hours💉 Route: SubQ injection⏱️ Cycle: 10–30 days

Follistatin 344 blocks myostatin — the protein that limits how much muscle your body can build — and animal research has shown dramatic increases in muscle mass when myostatin is inhibited.

Mechanism

Follistatin 344 binds and neutralizes myostatin (GDF-8) and activins. Myostatin limits muscle cell growth — blocking it allows for significant hypertrophy beyond the body's normal ceiling.

Research Protocol

ParameterValue
Dose100mcg daily
Cycle10–30 days maximum
5-Amino-1MQ
NNMT Inhibitor · Fat Cell Metabolism
EMERGING
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💊 Route: Oral capsule⏱️ Cycle: 4–8 weeks

5-Amino-1MQ targets fat cell metabolism at the enzyme level — animal research has shown it can reduce fat cell size and raise metabolic rate without affecting lean mass.

Mechanism

5-Amino-1MQ inhibits NNMT in fat cells, raising SAM levels and altering the epigenetic programming of adipocytes. This makes fat cells smaller and more metabolically active.

Research Protocol

ParameterValue
Dose50–100mg
RouteOral
FrequencyDaily
Survodutide
GLP-1/Glucagon Dual Agonist · Next-Gen Weight Loss
EMERGING
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📈 Half-life: ~5–6 days💉 Route: SubQ injection⏱️ Cycle: 24–48 weeks

Survodutide targets both GLP-1 and glucagon receptors — early trial data suggests stronger fat burning and liver fat reduction than GLP-1 alone. Currently in Phase 2 human clinical trials.

Mechanism

Survodutide activates GLP-1 receptors (appetite reduction, insulin sensitization) and glucagon receptors (increased energy expenditure, hepatic fat oxidation). Particularly effective for NASH and visceral adiposity.

Research Protocol

PhaseDose
Starting0.3mg weekly
TitrationUp to 4.8mg weekly
SS-31
Elamipretide · Mitochondria-Targeted Peptide
ADVANCED
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📈 Half-life: ~2–3 hours💉 Route: SubQ injection⏱️ Cycle: 4–8 weeks

SS-31 concentrates inside mitochondria and has shown the ability to restore energy production and reduce cellular stress in multiple disease models. Human clinical trials conducted for heart failure.

Mechanism

SS-31 selectively partitions into the inner mitochondrial membrane by targeting cardiolipin. It reduces mitochondrial ROS, improves membrane potential, and enhances ATP synthesis.

Research Protocol

ParameterValue
Dose1–5mg daily
RouteSubQ injection
Cycle4–8 weeks
Humanin
Mitochondrial Peptide · Neuroprotection
EMERGING
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📈 Half-life: ~1–2 hours💉 Route: SubQ injection⏱️ Cycle: 4–8 weeks

Humanin is produced by your own mitochondria and declines with age — preclinical studies have documented protective effects on brain cells, heart tissue, and metabolic health.

Mechanism

Humanin activates the FPRL1/gp130 receptor complex and STAT3 signaling, protecting neurons and cardiac cells from apoptosis. It also improves insulin sensitivity.

Research Protocol

ParameterValue
Dose2–4mg
Frequency3x weekly
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